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Clinical reference

EEG & qEEG

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77 terms
77 entries
Critical-care EEG

Anterior-posterior gradient

Expected AP gradient present, absent, or reversed.

Criteria & assessment

  • Present: clear persistent segment >=1 continuous min with lower-voltage/faster anterior and higher-voltage/slower posterior activity.
  • Reversed: same duration and paired criteria in the opposite direction.
Generation & measurement notes
  • Define quantitative 'clear' threshold.

Editorial draft · clinical review pending

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Critical-care EEG

Background reactivity

Cerebral response to stimulation: reactive, unreactive, SIRPIDs-only, unclear, or unknown.

Criteria & assessment

  • Qualifying change may be in cerebral voltage or frequency, including attenuation.
  • SIRPIDs-only: sole response is a stimulus-induced rhythmic, periodic, or ictal-appearing discharge.
  • Unclear: inadequate test, excessive artifact, or equivocal cerebral change. Unknown: not tested or maximally alert throughout.
Generation & measurement notes
  • Define stimulation protocol and cerebral-change threshold; S01 does not fully specify them.

Editorial draft · clinical review pending

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Critical-care EEG

Background symmetry

Symmetric, mildly asymmetric, or markedly asymmetric background.

Criteria & assessment

  • Mild: consistent voltage difference <50% on an appropriate referential recording or frequency difference 0.5–1 Hz.
  • Marked: voltage difference >=50% or frequency difference >1 Hz.
  • Consistent means >80% of relevant instances or record.
Generation & measurement notes
  • Choose the amplitude statistic and epoch aggregation for percent difference.

Editorial draft · clinical review pending

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Critical-care EEG

Background voltage

High, normal, low, or suppressed peak-to-trough background voltage.

Criteria & assessment

  • High: most/all activity >=150 µV.
  • Low: most/all activity <20 µV but not suppressed.
  • Suppressed: all activity <10 µV.
  • For nearly continuous/discontinuous records, use the higher-voltage portion.
Generation & measurement notes
  • Define 'most/all' and numeric normal bounds; S01 does not.

Editorial draft · clinical review pending

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Critical-care EEG

Breach effect

Breach effect present with location, absent, or unclear.

Criteria & assessment

  • Present: higher amplitude and increased sharpness, mainly faster frequencies, versus the rest of brain and especially the contralateral homologous region.
Generation & measurement notes
  • Define comparison thresholds and whether defect metadata is mandatory.

Editorial draft · clinical review pending

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Critical-care EEG

Brief potentially ictal rhythmic discharges

Brief potentially ictal rhythmic discharges with specified frequency, duration and morphology/context requirements.

Criteria & assessment

  • Focal (L/BI/UI/Mf) or generalized rhythmic activity >4 Hz, at least six waves at a regular rate, duration >=0.5 s and <10 s.
  • Exclude known normal/benign patterns, activity forming part of burst-suppression/attenuation, and definite clinical correlates.
  • Definite: evolution OR morphology AND location resembling interictal discharges or seizures in the same patient.
  • Possible: sharply contoured without either definite criterion.
  • Paroxysmal fast activity of the stated duration can qualify, focal or generalized, subject to the defining exclusions.

Editorial draft · clinical review pending

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Critical-care EEG

Burst attenuation/suppression modifiers

Timing, localization, morphology, highly epileptiform, and identical-burst descriptors.

Criteria & assessment

  • Burst averages >=0.5 s and has >=4 phases (>=3 baseline crossings); maximum duration 30 s.
  • Report location as generalized, lateralized, bilateral independent, unilateral independent, or multifocal; report typical burst/interburst durations and sharpest component.
  • Highly epileptiform: >=2 spikes/sharp waves in most (>50%) bursts at mean >=1 Hz within a burst, where frequency = 1 / typical interpeak latency; alternatively a rhythmic potentially ictal-appearing pattern occurs in most (>50%) bursts. Table 1 states >=1 Hz for this alternative, while A.4.d does not repeat that cutoff. Record frequency and location.
  • Identical: first >=0.5 s of each burst, or each stereotyped cluster of >=2 bursts, is visually similar in all channels in most (>90%) bursts.
Generation & measurement notes
  • Resolve the Table 1/A.4.d frequency-cutoff discrepancy; operationalize visual similarity and potentially ictal appearance.

Editorial draft · clinical review pending

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Critical-care EEG

Continuity and low-voltage percent

Continuity category from percent of a record/epoch occupied by attenuation or suppression.

Criteria & assessment

  • Attenuation: lower activity >=10 µV and <50% of higher-voltage background; suppression: lower activity <10 µV.
  • Continuous: low-voltage percent <1%.
  • Nearly continuous: 1–9%, with qualifying periods >=1 s; report typical duration.
  • Discontinuous: alternating higher activity with 10–49% attenuation/suppression.
  • Burst attenuation/suppression: alternating higher activity with 50–99% attenuation/suppression.
  • Suppression/attenuation: >99%; suppressed when all activity <10 µV, attenuated when all activity <20 µV but not suppressed.
  • For noncontinuous records report attenuation or suppression percent using record/epoch as denominator.
  • Stimulus-induced periods are SI-attenuation or SI-suppression.
Generation & measurement notes
  • Fix analysis epoch, boundaries, and handling of mixed attenuation plus suppression.

Editorial draft · clinical review pending

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Critical-care EEG

Cyclic alternating pattern of encephalopathy

Regular spontaneous alternation of two backgrounds: present, absent, or unknown/unclear.

Criteria & assessment

  • Each pattern lasts >=10 s and the pair alternates spontaneously/regularly for >=6 complete cycles; a cycle includes each state once.
  • Describe each pattern and typical duration; note awake/stimulated versus less-awake state when known.
  • If each pattern lasts >60 s, state-change criteria are also met.
Generation & measurement notes
  • Define tolerance for 'regular'; S01 does not.

Editorial draft · clinical review pending

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Critical-care EEG

Electroclinical seizure

An EEG pattern with a definite time-linked clinical correlate, or both EEG and clinical improvement after parenteral antiseizure medication.

Criteria & assessment

  • An EEG pattern with a definite time-locked clinical correlate, OR EEG AND clinical improvement after parenteral antiseizure medication.
  • A definite correlate must accompany the pattern and be absent when that pattern is absent; subtle signs can qualify.
  • Duration <10 s qualifies only with a definite clinical correlate. An ECSz need not meet ESz; report both when both qualify.

Editorial draft · clinical review pending

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Critical-care EEG

Electroclinical status epilepticus

Electroclinical seizures meeting status-duration or hourly-burden criteria, with a separate threshold for ongoing bilateral tonic-clonic activity.

Criteria & assessment

  • ECSz persists >=10 continuous minutes OR occupies >=20% of any 60-minute interval.
  • Exception: ongoing bilateral tonic-clonic motor seizure qualifies at >=5 continuous minutes.
  • Known epileptic encephalopathy additionally requires increased prominence/frequency of discharges from baseline with clinical deterioration, OR EEG and clinical improvement following parenteral antiseizure medication.

Editorial draft · clinical review pending

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Critical-care EEG

Electrographic seizure

An EEG event that meets the ACNS electrographic seizure criteria through discharge rate or definite evolution and duration.

Criteria & assessment

  • Either discharges averaging >2.5 Hz for >=10 s (>25 discharges/10 s), OR a pattern with definite evolution lasting >=10 s.
  • Sharply contoured discharges >200 ms may qualify through the high-rate pathway even when not technically epileptiform.
  • Evolution must satisfy the source RPP evolution criteria; amplitude change alone is insufficient.

Editorial draft · clinical review pending

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Critical-care EEG

Electrographic status epilepticus

Electrographic seizures meeting the ACNS continuous-duration or cumulative hourly-burden criteria for status.

Criteria & assessment

  • Qualifying ESz continues for >=10 minutes, OR total ESz duration is >=20% of any 60-minute interval.
  • Hourly burden uses the specified 60-minute denominator, not a cropped display's duration.

Editorial draft · clinical review pending

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Critical-care EEG

Ictal-interictal continuum

EEG patterns that do not meet definite seizure criteria but may contribute to impaired alertness, symptoms or neuronal injury in the appropriate clinical context.

Criteria & assessment

  • Always exclude ESz/ESE.
  • Pathway A: PD/SW averages >1 and <=2.5 Hz over 10 s.
  • Pathway B: PD/SW averages >=0.5 and <=1 Hz over 10 s AND (has a plus modifier OR fluctuation).
  • Pathway C: lateralized RDA averages >1 Hz for >=10 s AND (has a plus modifier OR fluctuation); includes LRDA, BIRDA, UIRDA and MfRDA.
  • IIC describes an electrographic category, not a diagnosis or an automatic treatment order.

Editorial draft · clinical review pending

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Critical-care EEG

Main term 1: localization

Main term 1 specifies the spatial organization of the RPP.

Criteria & assessment

allowed values
G
name
Generalized
rule
Bilaterally synchronous and symmetric, including a restricted field. Bilateral asymmetry or asynchrony that shifts and is not consistently lateralized to one side more than 80% of the time remains G.
qualifiers
predominance
frontally
anterior voltage at least 50% greater than posterior
occipitally
posterior voltage at least 50% greater than anterior
midline
midline voltage at least 50% greater than parasagittal
not otherwise specified
similar voltage in all regions and none of the preceding
asynchrony
For shifting asynchrony, record typical inter-side lag.
L
name
Lateralized
rule
Unilateral; or bilateral with clearly and consistently greater amplitude on one side; or bilateral with a consistent lead-in from one side. Includes focal, regional, and hemispheric patterns.
qualifiers
laterality
Specify side.
extent
  • unilateral
  • bilateral asymmetric
  • bilateral asynchronous
  • both asymmetric and asynchronous
consistency
Bilateral asymmetric and bilateral asynchronous examples require the same side more than 80% of the time.
lag
For bilateral asynchronous, record typical inter-side lag.
lobes
  • F
  • P
  • T
  • O
  • hemispheric if no finer localization
BI
name
Bilateral independent
rule
Two independent, therefore asynchronous, lateralized patterns, one in each hemisphere, occurring simultaneously (overlapping in time), not sequentially.
qualifiers
symmetry
  • symmetric
  • asymmetric with L > R or R > L
lobes
  • F
  • P
  • T
  • O
  • hemispheric
UI
name
Unilateral independent
rule
Two independent, therefore asynchronous, periodic or rhythmic patterns in the same hemisphere occurring simultaneously, not sequentially. A focal midline pattern can be ipsilateral to an independent left or right pattern.
qualifiers
per pattern
  • unilateral/bilateral extent
  • asymmetry/asynchrony if bilateral
  • side
  • most involved lobe(s)
Mf
name
Multifocal
rule
At least three independent lateralized patterns, with at least one in each hemisphere, all occurring simultaneously.
qualifiers
symmetry
  • symmetric
  • asymmetric with L > R or R > L
lobes
  • F
  • P
  • T
  • O
  • hemispheric
Generation & measurement notes
  • Store the main term and qualifiers independently; do not infer localization from a single channel label.

Editorial draft · clinical review pending

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Critical-care EEG

Main term 2: PDs, RDA, and SW

Main term 2 specifies the repeating waveform organization.

Criteria & assessment

PDs
name
Periodic discharges
rule
Relatively uniform waveform morphology and duration, a discernible inter-discharge interval, and recurrence at nearly regular intervals.
regularity
Cycle length varies by less than 50% from one cycle to the next in a majority (>50%) of cycle pairs.
discharge
Waveform shorter than 0.5 s irrespective of phases, or at least 0.5 s with no more than 3 phases; must stand out from background.
RDA
name
Rhythmic delta activity
rule
Relatively uniform waveform morphology and duration with no interval between waves; irregular or polymorphic delta is not RDA.
regularity
Period varies by less than 50% from the subsequent cycle in a majority (>50%) of cycle pairs.
frequency hz
min
0.5
max
4
note
Sharp crests or troughs do not prevent a pattern from being rhythmic.
SW
name
Spike-and-wave or sharp-and-wave
rule
Spike, polyspike, or sharp wave consistently followed by a slow wave in a regular alternating repeating pattern, with a consistent component relationship for at least 6 consecutive cycles and no interval between complexes.
Generation & measurement notes
  • Preserve source categories as enums; do not collapse PD, RDA, and SW into a generic rhythmicity class.

Editorial draft · clinical review pending

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Critical-care EEG

Minimum clinical reporting context

Recommended review, communication and reporting context for critical-care EEG.

Criteria & assessment

  • Review/report first 30–60 minutes promptly.
  • Written report at least once per 24 hours; significant intervening changes get separate epochs/reports.
  • Communication updates at least twice daily recommended except unusually stable circumstances.

Editorial draft · clinical review pending

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Critical-care EEG

Minor modifiers

Minor modifiers refine onset, morphology, lag, and polarity.

Criteria & assessment

onset
sudden
Absent to well-developed within 3 s.
gradual
Does not meet sudden-onset definition.
triphasic morphology
Three negative-positive-negative phases, each longer than the preceding and the positive phase of highest voltage; or positive-negative biphasic appearance when a low-voltage first negative phase is obscured by background. PDs and SW only.
anterior posterior lag
Consistent measurable delay >100 ms from most anterior to most posterior derivation, or reverse; report typical anterior-to-posterior delay in ms (negative for posterior-to-anterior) in longitudinal bipolar and referential montage, preferably ipsilateral-ear reference. PDs or spike/sharp component of SW only.
polarity
values
  • positive
  • negative
  • dipole, tangential
  • unclear
rule
Describe dominant/highest-voltage phase in a referential montage; PDs or spike/sharp component of SW only.
Generation & measurement notes
  • Keep conventional terminology and raw lag in milliseconds together; do not infer polarity from bipolar montage.

Editorial draft · clinical review pending

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Critical-care EEG

Nonconvulsive seizure/status qualifier

A qualifier indicating that a seizure or status event lacks prominent motor activity; it does not mean there is no clinical correlate.

Criteria & assessment

  • No prominent motor activity; applies to electrographic or electroclinical seizure/status.
  • Prefer nonconvulsive to subclinical: absence of prominent movement does not establish absence of clinical contribution.

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Critical-care EEG

Pattern/seizure burden and index

Measures of the duration or frequency-weighted duration of a pattern over an explicitly defined reporting interval.

Criteria & assessment

  • Daily burden: total pattern or seizure duration per 24 hours; hourly and maximal hourly burdens also reportable.
  • Daily pattern index: daily burden multiplied by mean frequency; retain units (Hz-hours or Hz-minutes).
Generation & measurement notes
  • Union overlapping intervals for occupied time; declare missing-data denominator policy in P3 rather than invent it as ACNS rule.

Editorial draft · clinical review pending

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Critical-care EEG

Phases, sharpness, and voltage modifiers

These modifiers describe discharge structure, contour, and amplitude.

Criteria & assessment

phases
formula
1 + number of baseline crossings of the typical discharge
montage
longitudinal bipolar, channel where most apparent
baseline rule
Start and end points are not crossings
bins
  • 1
  • 2
  • 3
  • >3
sharpness
spiky
component duration at EEG baseline <70 ms
sharp
70-200 ms
sharply contoured
steep slope on one side and/or pointed/apiculate inflection, but too long to be sharp
blunt
smooth or sinusoidal
required
Describe dominant (highest-voltage) phase and sharpest phase if different.
absolute voltage peak to trough uV
montage
standard longitudinal bipolar 10-20, channel where pattern is most apparent
PD measurement
highest-voltage component
SW measurement
spike/sharp component
bins
very low
<20
low
20-49
medium
50-149
high
>=150
relative voltage PDs only
Ratio of the highest-voltage component of the typical discharge to typical between-discharge background in the same channel and montage; bin as <=2 or >2.
Generation & measurement notes
  • Retain the acquisition montage with every amplitude, phase, and polarity-related field.

Editorial draft · clinical review pending

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Critical-care EEG

Plus modifier and extreme delta brush

Plus denotes an added feature that makes PDs or RDA more ictal-appearing than the unmodified pattern. Extreme delta brush is a specific +F subtype.

Criteria & assessment

subtypes
+F
Superimposed theta-or-faster activity, rhythmic or not, on PDs or RDA. It must be part of the pattern, not merely background; for PDs it may be continuous if absent when PDs are absent, or occur regularly with each discharge.
+R
Superimposed rhythmic or quasi-rhythmic delta activity; PDs only.
+S
Associated sharp waves, spikes, or sharp contour; RDA only; present at least once per 10 s and not an SW pattern.
combinations
  • PDs+FR
  • RDA+FS
bilateral rule
If a bilateral pattern qualifies for plus on only one side, the overall main term still receives the plus modifier.
EDB
definite
Abundant or continuous RDA+F with fast activity stereotypically related to the delta wave, or abundant/continuous PDs+F where each PD is a single blunt delta wave and fast activity is stereotypically related to that delta wave.
possible
Meets either EDB form but is only occasional/frequent, or the fast activity lacks a stereotyped delta-wave relationship.
not EDB
RDA+F/PDs+F lacking both required EDB conditions; a periodic pattern can be EDB only if PDs are blunt delta brushes; fast activity between delta waves or present as background does not qualify.
Generation & measurement notes
  • Encode plus subtypes as a set and EDB as a separately validated subtype; do not infer EDB from +F alone.

Editorial draft · clinical review pending

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Critical-care EEG

Possible electroclinical status epilepticus

A qualifying prolonged ictal-interictal continuum pattern that improves electrographically after parenteral antiseizure medication without clinical improvement.

Criteria & assessment

  • An IIC RPP persists >=10 continuous minutes OR >=20% of any 60-minute interval.
  • Parenteral antiseizure medication improves the EEG without clinical improvement.
  • All duration, IIC and response requirements are conjunctive.

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Critical-care EEG

Posterior dominant rhythm

Posterior dominant rhythm present with frequency, absent, or unclear.

Criteria & assessment

  • Present requires attenuation with eye opening.
  • Wait >1 s after eye closure before measuring frequency; report to nearest 0.5 Hz.
Generation & measurement notes
  • Define attenuation threshold and minimum observation duration; S01 does not.

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Critical-care EEG

Predominant background frequency

Band or tied bands most prominent when maximally awake or after stimulation.

Criteria & assessment

  • Categories: beta >13 Hz, alpha, theta, delta.
  • Report all 2 or 3 bands when equally prominent.
Generation & measurement notes
  • S01 gives no alpha/theta/delta boundaries or tie tolerance; version and review these separately.

Editorial draft · clinical review pending

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Critical-care EEG

Prevalence, duration, and frequency modifiers

These modifiers quantify how much pattern is present, its continuous run length, and its rate.

Criteria & assessment

prevalence percent record or epoch
continuous
>=90
abundant
50-89
frequent
10-49
occasional
1-9
rare
<1
denominator
proportion of the record or epoch that includes or is within the pattern; intervals between widely spaced PDs count as pattern duration
multiple patterns
Record each pattern and its own prevalence.
typical duration
very long
>=1 h
long
10-59 min
intermediate
1-9.9 min
brief
10-59 s
very brief
<10 s
also required
longest continuous duration
frequency hz
required
  • typical
  • minimum
  • maximum
categories
  • <0.5
  • 0.5
  • 1
  • 1.5
  • 2
  • 2.5
very brief additional categories
  • 3
  • 3.5
  • 4
PD SW restriction
Typical frequency >2.5 Hz is an RPP only when duration is <10 s; at >=10 s it is outside this RPP contract.
Generation & measurement notes
  • Store numeric measurements and categorical bins together so bins remain auditable.

Editorial draft · clinical review pending

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Critical-care EEG

RPP term construction and validity boundary

An RPP name combines one localization main term with one pattern-type main term, then adds applicable modifiers.

Criteria & assessment

required components
  • one main_term_1 localization
  • one main_term_2 pattern type
minimum run
consecutive cycles min
6
examples
  • 1 Hz for 6 s
  • 3 Hz for 2 s
frequency boundary
No RPP may have a typical frequency above 4 Hz. A pattern above 4 Hz lasting at least 0.5 s is outside this RPP contract; one shorter than 0.5 s is not an RPP.
evolution boundary
Within RPP terminology, evolution is limited to patterns at or below 4 Hz and shorter than 10 s. Longer evolving patterns and faster short patterns are delegated to the seizure/BIRD contracts.
Generation & measurement notes
  • Represent boundary handoffs as validation failures or external labels; do not derive seizure, BIRD, or IIC labels here.

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Critical-care EEG

Sporadic epileptiform discharge morphology

Nonrhythmic, nonperiodic spikes, sharp waves, and polyspikes.

Criteria & assessment

  • Spike: pointed transient distinct from background, duration >=20 ms and <70 ms at EEG baseline.
  • Sharp wave: same definition, duration >=70 ms and <=200 ms (source states 70–200 ms).
  • Polyspike: >=2 consecutive spikes with no interdischarge interval, total duration <0.5 s.
  • Typical, not required: diphasic/triphasic, apiculate, asymmetric slope, followed by slow wave or other background disruption.
Generation & measurement notes
  • S01 does not quantify pointedness/background disruption or explicitly discuss the 200-ms endpoint; adjudicate boundary cases.

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Critical-care EEG

Sporadic epileptiform discharge prevalence

Combined prevalence of spikes, polyspikes, and sharp waves.

Criteria & assessment

  • Abundant: >=1/10 s, but not periodic.
  • Frequent: >=1/min and <1/10 s.
  • Occasional: >=1/h and <1/min.
  • Rare: <1/h.
  • When abundant, mean and maximum count per 10-s epoch may be recorded.
Generation & measurement notes
  • S01 provides no explicit absent category; represent zero events separately pending review.

Editorial draft · clinical review pending

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Critical-care EEG

State changes and N2 transients

Sustained alertness/stimulation-related backgrounds with separate N2-transient characterization.

Criteria & assessment

  • Present requires >=2 background types, each sustained >=60 s.
  • Stimulation should transition less-alert to more-alert/stimulated; spontaneous transitions qualify; the more-alert state is primary.
  • State changes virtually always imply reactivity; reactivity need not imply a state change when it lasts <60 s.
  • Categories: present with normal N2 transients; present with abnormal N2 transients; present without N2 transients; absent.
  • Describe K-complexes and spindles separately: present-normal, present-abnormal with abnormality, or absent.
Generation & measurement notes
  • Define persistence across brief artifact and structured N2 abnormalities.

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Critical-care EEG

Stimulus state, evolution, fluctuation, and static modifiers

Stimulus modifiers describe reproducible response to alerting stimulation; temporal modifiers describe frequency, morphology, or location change.

Criteria & assessment

stimulus state
SI
Reproducibly brought about or exacerbated by alerting stimulus in a less-stimulated state, with or without clinical alerting; may also occur spontaneously.
ST
Reproducibly terminated or attenuated by alerting stimulus in a less-stimulated state, with or without clinical alerting; may also self-terminate.
spontaneous
Never clearly induced, exacerbated, improved, or terminated by stimulation.
unknown
Unclear or untested.
stimulus type required
  • auditory
  • light tactile
  • patient care/other nonnoxious
  • noxious
evolving
minimum
At least 2 unequivocal sequential changes in the same category.
frequency
Two consecutive changes in one direction, each at least 0.5 Hz; each frequency persists at least 3 cycles.
morphology
Two consecutive novel morphologies; each morphology, including transition forms, persists at least 3 cycles.
location
Sequential spread into or out of at least 2 standard 10-20 electrode locations; involvement of each additional electrode persists at least 3 cycles.
interstep gap
Reach criteria without the changing feature remaining unchanged for 5 or more continuous minutes.
amplitude
Voltage/amplitude change alone is neither evolution nor a new morphology.
fluctuating
minimum
At least 3 changes, no more than 1 minute apart, not qualifying as evolution.
frequency
Each change at least 0.5 Hz; each frequency persists at least 3 cycles.
morphology
Each morphology persists at least 3 cycles.
location
Each change at least 1 standard interelectrode distance; each location persists at least 3 cycles.
amplitude
Voltage/amplitude change alone is not fluctuation.
static
Neither evolving nor fluctuating.
additional reporting
If evolving or fluctuating in frequency, specify minimum and maximum frequency. For nongeneralized patterns specify spread as none, unilateral, or bilateral.
Generation & measurement notes
  • Use an event sequence rather than a single classifier score so cycle persistence, direction, and interstep gap can be audited.

Editorial draft · clinical review pending

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Critical-care EEG

Stimulus-induced seizure/IIC/BIRDs qualifier

A qualifier for a qualifying pattern reproducibly induced or exacerbated by an alerting stimulus.

Criteria & assessment

  • Alerting stimulus reproducibly induces or exacerbates the qualifying phenomenon; prepend SI to the qualifying term.

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Neonatal EEG

ACNS neonatal monitoring indications

Current ACNS guidance on indications for continuous EEG monitoring in neonates.

Criteria & assessment

  • Consult the final January 2025 guideline linked from the ACNS index.

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Neonatal EEG

Background symmetry and interhemispheric synchrony

Symmetry compares homologous content and voltage; synchrony compares burst onset timing and has a non-linear developmental course.

Criteria & assessment

  • Persistent >2:1 voltage difference between homologous regions, or persistent disparity in frequency or graphoelement distribution, is abnormal asymmetry; fleeting differences may remain normal.
  • A burst pair is synchronous when left and right onsets differ by <=1.5 seconds; report the percentage of synchronous bursts.
  • Near-complete synchrony is expected before roughly 27-29 weeks and again near term; about 70% synchrony may occur around 29-30 weeks and some asynchrony is expected from 30-37 weeks.
  • After 38 weeks PMA, substantial asynchrony is not expected; abnormal asynchrony means a clearly excessive PMA-adjusted proportion of bursts with onset difference >1.5 seconds.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 9 ↗

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Neonatal EEG

Background variability and reactivity

Variability is spontaneous change from internal state; reactivity is cerebral EEG change after external stimulation.

Criteria & assessment

  • A qualifying response is a conspicuous change in frequency, continuity, or voltage.
  • Record each feature as yes, no, or unclear/unknown/not applicable.
  • Variability first appears near 25 weeks PMA, increases by 28 weeks, and is well established around 30-31 weeks.
  • Reactivity first appears around 30-32 weeks PMA; record stimulus type and strength.
  • Separate cerebral change from movement, EMG, crying, and respiratory artifacts; arousal-related voltage attenuation is not automatically discontinuity.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 11 ↗

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Neonatal EEG

Behavioral state and sleep-wake cycling

State assignment combines EEG and polysomnographic behavior and is interpreted relative to PMA.

Criteria & assessment

  • A state requires its defining features for >=60 seconds.
  • Allowed states are awake, active sleep, quiet sleep, transitional sleep, and indeterminate sleep; transitional sleep mixes features of the states on either side, while indeterminate sleep cannot be assigned to active or quiet sleep.
  • Term awake and active sleep use continuous low-to-medium voltage mixed-frequency activité moyenne; active sleep additionally has closed eyes, REM, irregular respiration, and body movement.
  • Term quiet sleep has closed eyes, absent REM, little movement, and near term commonly tracé alternant; mature continuous high-voltage slow activity and 10-12 Hz spindles emerge around 46 weeks PMA.
  • Sleep-wake cycling records orderly alteration among states: term complete sleep-wake cycles are typically 3-4 hours and sleep-only cycles 40-70 minutes; preterm sleep cycles are 30-50 minutes below 35 weeks PMA and 50-65 minutes beyond 35 weeks PMA.
  • Unspecified state change requires distinct EEG patterns differing in discontinuity, voltage, or frequency, with each state lasting >=60 seconds.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 4 ↗

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Neonatal EEG

Brief rhythmic discharge

An evolving rhythmic neonatal discharge resembling seizure activity but lasting less than ten seconds.

Criteria & assessment

  • Rhythmic electrical activity shows evolution and duration <10 seconds.
  • Record accompanying background abnormality and confirmed seizures; these are common contexts but not stated as mandatory criteria.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 14 ↗

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Neonatal EEG

EEG dysmaturity

The EEG background appears developmentally appropriate for an infant at least two weeks younger than the actual PMA.

Criteria & assessment

  • Difference between actual PMA and EEG-implied PMA is >=2 weeks.
  • Persistent dysmaturity is abnormal; the source frames the concept longitudinally.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 12 ↗

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Neonatal EEG

Excessive discontinuity and neonatal burst suppression

Separates PMA-inappropriate discontinuity that retains normal elements from invariant burst suppression lacking normal graphoelements.

Criteria & assessment

  • Excessive discontinuity has IBIs too long or too voltage-depressed for PMA while bursts retain some age-appropriate patterns or graphoelements.
  • Burst suppression has invariant abnormal bursts separated by prolonged IBIs with voltage <5 µV peak-to-peak.
  • Permitted activity within burst-suppression IBIs is limited to sparse activity up to 15 µV in one electrode, transient activity up to 15 µV for <2 seconds, or the source-described >2:1 voltage asymmetry in multiple electrodes.
  • Burst suppression is unreactive and lacks spontaneous lability; bursts lack recognizable normal graphoelements and should be described as >100 µV or <100 µV, with typical burst and IBI durations and burst-component sharpness recorded.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 8 ↗

Editorial draft · clinical review pending

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Neonatal EEG

ILAE neonatal seizure framework

The neonatal framework emphasizes EEG-confirmed seizures and distinguishes electrographic-only from electroclinical events.

Criteria & assessment

  • Document EEG evidence and available clinical correlate.

Editorial draft · clinical review pending

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Neonatal EEG

Neonatal recording context and daily reporting

Minimum context needed to interpret each 24-hour neonatal continuous video-EEG period and its clinically relevant changes.

Criteria & assessment

  • Record postmenstrual age (PMA) at acquisition; PMA is gestational age from last menstrual period plus chronological age.
  • Source categories are preterm <37 weeks PMA, term 37 up to 44 weeks PMA, and post-term 44 to 48 weeks PMA; the literal wording overlaps at 44 weeks and does not state whether 48 weeks is inclusive.
  • Record neuroactive medications and ideally administration times, including sedatives, hypnotics, anxiolytics, anesthetics, and antiseizure drugs.
  • Record hypothermia depth, duration, and whether spontaneous or induced; record major hemodynamic, respiratory, or cardiorespiratory changes.
  • Record hours uninterpretable for technical reasons; characterize the first hour, one background hour in each later 24-hour period, and additional epochs after relevant change.
  • Record seizure onset, burden, resolution, and status epilepticus onset and resolution.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 3 ↗
Generation & measurement notes
  • Pending Craig: encode term as the half-open interval [37,44) weeks and post-term as beginning at 44 weeks; the upper 48-week boundary remains unresolved.

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Neonatal EEG

Neonatal rhythmic and periodic patterns of uncertain significance

Non-seizure periodic discharges and rhythmic delta activity are described by waveform organization, minimum cycles, onset, spread, and neonatal location terms.

Criteria & assessment

  • Periodic discharges have relatively uniform morphology/duration, a measurable interdischarge interval, and near-regular recurrence: cycle length varies <50% between adjacent cycles in >50% of cycle pairs.
  • A discharge has <=3 phases or lasts <=0.5 seconds regardless of phases; a burst lasts >0.5 seconds and has >=4 phases.
  • RDA repeats relatively uniform waveforms without an inter-wave interval and has cycle-length variation <50% in >50% of adjacent cycle pairs.
  • PD or RDA must persist for >=6 cycles.
  • Location is lateralized, diffuse with asynchronous all-electrode involvement, bilateral independent, or multifocal; report onset focus, maximal spread, and F/C/T/O/Z or hemispheric predominance as applicable.
  • For diffuse patterns, frontal, occipital, or midline predominance requires amplitude >=50% greater than the comparison region in an appropriate referential montage.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 17 ↗

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Neonatal EEG

Neonatal rhythmic/periodic duration, polarity, and sharpness modifiers

Neonatal RPPs use a limited modifier set with neonatal duration boundaries and bipolar polarity measurement.

Criteria & assessment

  • Record typical duration and preferably longest continuous duration: very long >=1 hour; long 5-59 minutes; intermediate 1-4.9 minutes; brief 10-59 seconds; very brief <10 seconds without evolution.
  • Determine predominant-phase polarity in a traditional bipolar montage as positive, negative, or unclear.
  • Measure sharpness at baseline for predominant and sharpest phase: spiky <100 ms; sharp 100-200 ms; sharply contoured theta/delta is >200 ms with steep or pointed morphology; blunt is smooth or sinusoidal.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 18 ↗

Editorial draft · clinical review pending

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Neonatal EEG

Neonatal seizure burden and status epilepticus

Seizure burden is quantified over an explicit denominator; neonatal status is defined by seizure occupancy of a one-hour epoch.

Criteria & assessment

  • Clinical burden may be reported as seizure count per hour or total seizure duration divided by the duration of the epoch of interest.
  • Research temporal-spatial burden sums seizure duration per hour in five non-overlapping neonatal montage regions so each electrode is counted once; the source lists Fp3-T3, C3-O1, Fp4-T4, C4-O2, Fz-Pz or an alternate pairing.
  • Status epilepticus is present when summed seizure duration is >=50% of any defined 60-minute epoch.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 16 ↗

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Neonatal EEG

Neonatal seizure type, electrographic definition, and spread

A neonatal electrographic seizure is a sudden abnormal repetitive evolving EEG event meeting voltage and duration thresholds; clinical coupling is classified separately.

Criteria & assessment

  • Electrographic seizure is repetitive and unequivocally evolves in frequency, voltage, morphology, or location, reaches >=2 µV peak-to-peak, and lasts >=10 seconds; there is no minimum electrical frequency.
  • The 2 µV threshold marks seizure beginning and end; two events are separate only when the inter-event interval is >=10 seconds.
  • Electroclinical seizure has definite simultaneous clinical seizure signs; electrographic-only seizure has no specific visible clinical sign; clinical-only events have no simultaneous EEG seizure.
  • Spread classes are diffuse asynchronous involvement of all electrodes, bilateral independent, migrating between hemispheres, lateralized within one hemisphere, unifocal onset, or multifocal onset from >=3 independent foci with >=1 in each hemisphere.
  • Restricted locations may be frontal, central, temporal, occipital, vertex, anterior quadrant, posterior quadrant, or hemispheric left/right.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 15 ↗

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Neonatal EEG

Neonatal sharp-wave transients

Distinct positive or negative transients are classified using baseline duration, abundance, spatial distribution, repetition, PMA, and background context.

Criteria & assessment

  • A spike lasts <100 ms at baseline; a sharp wave lasts 100-200 ms; the transient must stand apart from background rather than be only sharply contoured background.
  • Physiologic negative sharp waves are usually 100-200 ms, solitary, symmetric, and mid-temporal/central/centro-temporal against a PMA-normal background; frontal, vertex, and occipital locations are uncommon.
  • Abnormal negative transients are supported by abnormal background, concentration in one region or hemisphere, atypical location, high abundance, or repetitive runs; source-cited outcome data call rates >11/hour preterm and >13/hour term abnormal.
  • Positive Rolandic/vertex sharp waves are centered at C3/C4 or vertex with adjacent field; excessive positive mid-temporal waves can indicate focal pathology, while cited upper normal observations are 3/hour preterm and 1.5/hour term.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 13 ↗

Editorial draft · clinical review pending

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Neonatal EEG

Normal continuity, tracé discontinu, and tracé alternant

Normal neonatal continuity and discontinuity are PMA- and state-dependent rather than fixed adult categories.

Criteria & assessment

  • Continuous activity has no interruption and <2 seconds of attenuation below 25 µV peak-to-peak.
  • An interburst interval (IBI) is attenuation below an age-dependent level described broadly as <25-50 µV peak-to-peak for >=2 seconds; Table 1 supplies the age bins.
  • Normal maximum IBI/voltage by PMA: <30 weeks, 35 seconds and <25 µV; 30-33 weeks, 20 seconds and <25 µV; 34-36 weeks, 10 seconds and approximately 25 µV; 37-40 weeks, 6 seconds and >25 µV.
  • Tracé discontinu contains 50-300 µV bursts with low-voltage IBIs and age-appropriate graphoelements; it is developmentally expected mainly from 26-40 weeks PMA and becomes confined to quiet sleep with maturation.
  • Tracé alternant occurs only in quiet sleep: 50-150 µV delta bursts lasting roughly 4-10 seconds alternate with 25-50 µV mixed theta-delta periods that never fall below 25 µV; it appears around 34-36 weeks, is minimal by 42 weeks, and is absent by 46 weeks PMA.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 5 ↗

Editorial draft · clinical review pending

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Neonatal EEG

Normal neonatal graphoelements

Named developmental background hallmarks whose morphology, state, distribution, and expected PMA window jointly determine normality.

Criteria & assessment

  • Monorhythmic delta: 24-34 weeks PMA, up to 200 µV peak-to-peak, stereotyped delta usually occipital, temporal, or central and rarely frontal; typically symmetric, synchronous, and often surface positive.
  • Delta brushes: most prominent 24-36 weeks, 0.3-1.5 Hz slow waves at 50-250 µV with superimposed 8-12 or 18-22 Hz activity; peak expression 32-34 weeks, with state distribution changing by PMA and occasional quiet-sleep occurrence through 40 weeks.
  • Rhythmic temporal theta: 24-34 weeks, 25-120 µV theta in approximately 2-second temporal bursts, typically symmetric and maximal at 29-32 weeks; similar activity may occur at vertex or occipital sites.
  • Anterior dysrhythmia: 32-44 weeks, 50-100 µV frontal delta waves singly or in brief runs, typically symmetric and synchronous.
  • Encoches frontales: 34-44 weeks, 50-100 µV broad diphasic frontal transients lasting 0.5-0.75 seconds with small initial negative and larger positive phase; typically symmetric/synchronous and enriched during transition from active to quiet sleep.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 12 ↗

Editorial draft · clinical review pending

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Neonatal EEG

Term background voltage and electrocerebral inactivity

Voltage categories for term neonatal background plus the separately standardized technical claim of electrocerebral inactivity (ECI).

Criteria & assessment

  • Normal term background has most activity >=25 µV peak-to-peak in every behavioral state.
  • Borderline low voltage is continuous, retains normal activity and graphoelements, and is persistently >=10 and <25 µV peak-to-peak.
  • Low-voltage suppressed background lacks normal features, has fundamental baseline <10 µV peak-to-peak, permits >=10 µV transients only when <2 seconds, and is invariant and unreactive.
  • ECI means no discernible cerebral activity at or above 2 µV peak-to-peak when reviewed at sensitivity 2 µV/mm and only when ECI technical standards were met; otherwise report only that the record may be consistent with ECI.
Source · 2012 guideline / 2013 publicationACNS neonatal terminology, official PDF · PDF p. 10 ↗

Editorial draft · clinical review pending

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qEEG

Alpha/delta ratio

Alpha-band power divided by delta-band power under stated band definitions.

Criteria & assessment

  • Inspect numerator, denominator and raw EEG; retain units and aggregation settings.

Editorial draft · clinical review pending

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qEEG

Amplitude envelope

A time-varying summary of signal amplitude after specified processing.

Criteria & assessment

  • State filtering, rectification or analytic-envelope method, smoothing and units.

Editorial draft · clinical review pending

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qEEG

Amplitude-integrated EEG

A compressed amplitude display whose envelope depends on filtering, derivation and processing.

Criteria & assessment

  • Inspect upper/lower margins and raw EEG at matching times.

Editorial draft · clinical review pending

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qEEG

Change from baseline

A comparison with a selected reference interval using stated arithmetic.

Criteria & assessment

  • Show reference interval; distinguish dB power differences from percentage scalar changes.

Editorial draft · clinical review pending

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qEEG

FFT spectrogram / CDSA

A time-frequency representation of signal power.

Criteria & assessment

  • Read frequency, time and color scale together; verify derivation, FFT window and overlap.

Editorial draft · clinical review pending

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qEEG

Quantitative asymmetry

A defined comparison of homologous left/right signal measurements.

Criteria & assessment

  • State formula, sign convention, bands and montage.

Editorial draft · clinical review pending

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qEEG

Rhythmicity trend

An algorithm-dependent measure of sustained rhythmic signal structure.

Criteria & assessment

  • Inspect the actual algorithm and aligned raw EEG before assigning a clinical label.

Editorial draft · clinical review pending

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qEEG

Seizure probability / detector illustration

A detector output whose interpretation depends on algorithm validation and calibration.

Criteria & assessment

  • Review aligned raw EEG for every apparent detection.

Editorial draft · clinical review pending

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qEEG

Suppression ratio

Fraction of a specified analysis interval meeting the algorithm's suppression rule.

Criteria & assessment

  • Report voltage rule, epoch length, averaging window and derivation.

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qEEG

Theta/delta ratio

Theta-band power divided by delta-band power under stated band definitions.

Criteria & assessment

  • State frequency bands, montage and smoothing; compare both underlying powers.

Editorial draft · clinical review pending

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qEEG

Total power

Power integrated across a stated frequency range.

Criteria & assessment

  • Specify band limits, units and derivation.

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Normal variants

14-and-6 positive bursts

Brief positive posterior-temporal bursts in drowsiness or light sleep.

Criteria & assessment

  • Use a reference that demonstrates positive polarity; inspect both burst envelope and frequency.

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Normal variants

Lambda waves

Positive occipital transients associated with visual scanning.

Criteria & assessment

  • Verify occipital field and positive polarity with an appropriate reference.

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Normal variants

Mu rhythm

Central arciform rhythm that can attenuate with movement or sensorimotor activation.

Criteria & assessment

  • Compare central distribution with the posterior dominant rhythm.
  • Document the movement interval when claiming blocking.

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Normal variants

Positive occipital sharp transients of sleep

Positive occipital sleep transients, sometimes in trains.

Criteria & assessment

  • Demonstrate occipital field and positive polarity.

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Normal variants

Rhythmic midtemporal theta of drowsiness

Temporal theta trains without ictal evolution in a drowsy background.

Criteria & assessment

  • Review onset, middle and offset before judging evolution.

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Normal variants

SREDA

Subclinical rhythmic EEG discharge of adults, a seizure mimic with a characteristic clinical and electrographic context.

Criteria & assessment

  • Assess bilateral distribution, evolution and clinical state.

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Normal variants

Wicket waves

Arciform temporal activity occurring singly or in trains.

Criteria & assessment

  • Assess background continuity, temporal field, and absence of a stereotyped epileptiform after-going slow wave.

Editorial draft · clinical review pending

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Artifacts

ECG and pulse artifact

Electrical cardiac contamination and mechanical pulse artifact are different phenomena.

Criteria & assessment

  • Compare timing with an ECG channel before asserting cardiac coupling.

Editorial draft · clinical review pending

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Artifacts

Electrode and environmental artifacts

Noncerebral signals can imitate slow waves, sharp transients or rhythmic activity.

Criteria & assessment

  • Inspect electrode field, frequency, onset/decay, filters and external timing.

Editorial draft · clinical review pending

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Artifacts

Muscle and chewing artifact

Muscle activity can introduce fast activity and contaminate spectral trends.

Criteria & assessment

  • Compare spatial distribution and raw waveform with high-frequency power.

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Artifacts

Ocular artifact

Eye-generated potentials with a characteristic frontal field.

Criteria & assessment

  • Distinguish vertical blinks from opposed lateral fields; document EOG or behavior when available.

Editorial draft · clinical review pending

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Activation

Hyperventilation buildup

Increased slow activity during hyperventilation, particularly prominent in children.

Criteria & assessment

  • Review pre-activation baseline, activation and recovery.

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Activation

Photic driving

Posterior rhythmic response related to the flash rate or its harmonics.

Criteria & assessment

  • Show stimulus frequency and timing.

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Developmental EEG

Hypnagogic hypersynchrony

Prominent synchronous slow activity during childhood drowsiness.

Criteria & assessment

  • Evaluate diffuse distribution, state transition and waveform morphology.

Editorial draft · clinical review pending

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Developmental EEG

Hypsarrhythmia

Disorganized high-amplitude slow activity with multifocal epileptiform discharges.

Criteria & assessment

  • Assess organization, multifocality, amplitude and state dependence.

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Seizure classification

ILAE seizure classification (2025)

The current ILAE classification retains focal, generalized, unknown whether focal or generalized, and unclassified seizures.

Criteria & assessment

  • Keep seizure classification distinct from an EEG pattern label.
  • Preserved/impaired consciousness requires clinical evidence.

Editorial draft · clinical review pending

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Terminology

IFCN EEG terminology

Standardized terms for describing clinical EEG and reporting findings.

Criteria & assessment

  • Use waveform description separately from clinical interpretation.

Editorial draft · clinical review pending

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